BD Simplist™ a line of ready-to-administer prefilled injectables designed with high safety standards in mind: yours1
INDICATIONS AND USAGE
Morphine sulfate is an opioid agonist indicated for the management of pain not responsive to non-narcotic analgesics.
Important Safety Information
Morphine sulfate is contraindicated in:
WARNINGS AND PRECAUTIONS
- patients with known hypersensitivity to morphine.
- patients with respiratory depression in the absence of resuscitative equipment.
- patients with acute or severe bronchial asthma or hypercarbia.
- any patient who has or is suspected of having paralytic ileus.
- Dosing errors: Take care when prescribing and administering to avoid dosing errors due to confusion between different concentrations and between mg and mL, which could result in accidental overdose and death.
- Cardiovascular instability: High doses are excitatory, resulting from sympathetic hyperactivity and increase in circulatory catecholamines.
- Respiratory depression: Rapid intravenous administration may result in chest wall rigidity.
- CNS toxicity: High doses are excitatory, resulting in convulsions.
- CNS depressants: May increase the risk of respiratory depression, hypotension, sedation, coma, or death if used in conjunction with other CNS active drugs.
- Increased intracranial pressure or head injury: May increase respiratory depressant effects and elevate cerebrospinal fluid pressure.
- Hypotensive effect: May cause severe hypotension in ambulatory patients.
- Gastrointestinal effects: May diminish propulsive peristaltic waves in the gastrointestinal tract and prolong obstruction.
- Biliary Surgery or disorders of the biliary tract: May cause spasm of the sphincter of Oddi and diminish biliary and pancreatic secretions.
Serious adverse reactions associated with Morphine Sulfate Injection, USP include, respiratory depression, apnea, and to a lesser degree, circulatory depression, respiratory arrest, shock and cardiac arrest. The most frequently observed adverse reactions include sedation, lightheadedness, dizziness, nausea, vomiting, constipation and diaphoresis.
- CNS depressants: increased risk of respiratory depression, hypotension, profound sedation and coma.
- Muscle relaxants: may enhance the neuromuscular blocking action of skeletal muscle relaxants and produce respiratory depression.
- Mixed agonist/antagonist opioid analgesics: May reduce the analgesic effect and/or may precipitate withdrawal symptoms.
- Cimetidine: May increase respiratory and CNS depression.
- Monoamine Oxidase Inhibitors (MAOIs): potentiate the action of Morphine Sulfate Injection, USP
- Anticholinergics: May increase the risk of urinary retention, severe constipation or paralytic ileus.
Before administering Morphine Sulfate Injection, please read the full prescribing information